San Francisco 49ers quarterback Brock Purdy missed last week's game against the Green Bay Packers. Will he play against the ...

Colin Cowherd believes that the Buffalo Bills are the best team in the NFL when playing at full strength. Somebody forgot to ...

Former Buffalo Bills quarterback Ryan Fitzpatrick recently sang the praises of current field general Josh Allen.

The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on "Sunday Night Football" in Week 13. The ...

Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...

On Tuesday, we reported on Buffalo’s sterling record following bye weeks under Head Coach Sean McDermott, which was quickly ...

Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

Now that the holiday season is in full swing, several Bills players are taking the time to be active in the community. A ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

Simpson carried the ball 29 times against the Lions and set a new NFL record with 273 rushing yards, breaking his own record ...