San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

Watching NFL games, including Fox broadcasts, is simple with Hulu + Live TV, which includes 90 channels, unlimited DVR ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

San Francisco 49ers star linebacker Fred Warner revealed that he has been playing through a broken bone in his ankle since ...

San Francisco 49ers quarterback Brock Purdy was limited with the right shoulder injury that sidelined him last week and there ...

This is the fifth time the Bills are playing in prime-time this year and they are 3-1, though the loss did come in their only ...

San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...