San Francisco isn't a stranger to taking chances on former starters. The 49ers had Sam Darnold on the roster last year and he ...

One San Francisco 49ers star has been dealing with more pain than was previously known for most of the season.

The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a ...

T he Buffalo Bills are on the brink of their first 10-2 start since 1991, as they'll host the defending NFC Champion San ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

Limited, but barely throws Wednesday ...

Deebo Samuel probably is the most disappointing player on the most disappointing team in the NFL through 12 weeks. Despite ...

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

San Francisco 49ers head coach Kyle Shanahan told reporters that star quarterback Brock Purdy will practice with the team ...

Fred Warner has played through pain before. However, he made a stunning admission about one ailment he's playing with.