Playing in overtime in the season finale against the Falcons, Winston threw a pass on the first and only OT play from scrimmage and the ball landed in the arms of Atlanta linebacker Deion Jones, who took it 27 yards the other way to give his team a 28-22 win.

Ja'Quan McMillian had the biggest pick-six as it came in the final minutes of the game. The Broncos were up 34-32 and the Browns were driving down the field trying to get in field goal position to win the game. Winston made a mistake, and McMillian took advantage of it as he took the pick to the house, and that sealed the win for the Broncos.

The Denver Broncos hung on to defeat the Cleveland Browns 41-32 in a wild Monday Night Football game in Week 13. Browns quarterback Jameis Winston had a huge game with 497 passing